alpha-Lobeline hydrochloride

Product Name: alpha-Lobeline hydrochloride
CAS No.: 134-63-4
Chemical Name: alpha-Lobeline hydrochloride
Synonyms: Lobelin Hydrochlorde;LOBELINE HYDROCHLORIDE;(-)-id;a-Lobeline;A-LOBELINE HCL;(-)-LOBELINE HCL;LOBELINE HCL, A-;Einecs 205-150-2;ALPHA-LOBELIN HCL;Lobeline HCl salt
CBNumber: CB9404885
Molecular Formula: C22H28ClNO2
Formula Weight: 373.92
MOL File: 134-63-4.mol

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alpha-Lobeline hydrochloride Property

Melting point:: 183-185 °C (dec.)(lit.)
alpha: D20 -43° (c = 2)
refractive index: -57.5 ° (C=1, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: H₂O: 25 mg/mL
form: powder
color: white to off-white
optical activity: [α]20/D 56.8°, c = 2 in H2O
Merck: 14,5551
BRN: 3920196
LogP: 3.610 (est)
CAS DataBase Reference: 134-63-4(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 23/25
Safety Statements: 36/37/39-45
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
RTECS: OJ8490100
F: 8
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000112
Product name: Lobeline hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000112
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: 141879
Product name: (?)-Lobeline hydrochloride
Purity: 98%
Packaging: 1g
Price: $304
Updated: 2024/03/01

Cayman Chemical

Product number: 29526
Product name: (–)-Lobelin (hydrochloride)
Packaging: 250mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 29526
Product name: (–)-Lobelin (hydrochloride)
Packaging: 500mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 29526
Product name: (–)-Lobelin (hydrochloride)
Packaging: 1g
Price: $143
Updated: 2024/03/01

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alpha-Lobeline hydrochloride Chemical Properties,Usage,Production

Description

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (K_i = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

Chemical Properties

White to Off-White Solid

Uses

A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant

Uses

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

Biological Activity

High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.

in vitro

clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]

in vivo

male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

alpha-Lobeline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-Lobeline hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 158 Europe 1 France 2 Germany 6 India 7 Japan 1 Switzerland 3 United Kingdom 13 United States 35 Venezuela 1 Global 230

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View Lastest Price from alpha-Lobeline hydrochloride manufacturers

Wuhan Monad Medicine Tech Co.,LTD

Product: Lobeline hydrochloride 134-63-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%min
Supply Ability: 5000
Release date: 2021-04-16

Dideu Industries Group Limited

Product: alpha-Lobeline hydrochloride 134-63-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

Career Henan Chemical Co

Product: alpha-Lobeline hydrochloride 134-63-4
Price: US $1.00/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-09

134-63-4, alpha-Lobeline hydrochlorideRelated Search:

Diethylstilbestrol N-Ethylmethylamine Lobeline Methyl salicylate 1-AdaMantanethylaMine 2'-Hydroxyacetophenone Kresoxim-methyl PHENYL VALERATE Thiophanate-methyl Topotecan hydrochloride Tribenuron methyl α-Lipoic Acid 3,4-Dihydroxyacetophenone 1-Hydroxyethylidene-1,1-diphosphonic acid 4-Ethyl-5-fluoro-6-hydroxypyrimidine 3'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 3-Nitroacetophenone

(-)-id

2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor

2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone

Lobelinhydrochloride

2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone

Lobelin Hydrochlorde

2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL

2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE

2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride

[2-[(2R,6S)-6-[(2S)-2-HYDROXYPHENETHYL]]-1-METHYL-2-PIPERIDYL]ACETOPHENONE HYDROCHLORIDE

(-)-LOBELINE HCL

LOBELINE HCL, A-

(-)-LOBELINE HYDROCHLORIDE

LOBELINE HYDROCHLORIDE

L-LOBELINE HYDROCHLORIDE

A-LOBELINE HCL

A-LOBELINE, HYDROCHLORIDE

ALPHA-LOBELINE HYDROCHLORIDE

ALPHA-LOBELIN HCL

2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride

2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride

a-Lobeline

Lobeline HCl salt

Apolipoprotein B (LDL), Sheep anti-Human, Guinea pig, Swine (NO X w/Bovine, Horse, Dog, Cat, Rabbit, Chicken, Goat, Mouse, Rat)

2-[(6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenylethanone

a-Lobeline Hydrochloride (L-Lobeline hydrochloride

2-[6-(beta-Hydroxyphenylethyl)-1-methyl-2-piperidinyl]acetophenone hydrochloride

Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride, (-)-

Einecs 205-150-2

Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride

Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride, (2R-(2alpha,6alpha(S*))-

α-Lobeline Hydrochcloride

2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenonehydrochloride

Lobeline hydrochloride ,99%

α-Lobeline hydrochloride,2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride, ()-Lobeline hydrochloride

2-[1-chloro-6-(2-hydroxy-2-phenylethyl)-1-Methyl-1$l^{5}-piperidin-2-yl]-1-phenylethan-1-one

2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-Methyl-2-piperidinyl]-1-phenylethanone Hydrochloride

2-[6-(2-hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride

(-)-Lobeline hydrochloride, 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride

α-Lobeline hydrochloride, L-Lobeline hydrochloride

2-(6-(2-Hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl)-1-phenylethanone hydrochloride

Lobeline hydrochloride CRS

2-((2R,6S)-6-((S)-2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one hydrochloride

alpha-Lobeline hydrochloride USP/EP/BP

(-)-a-Lobeline Hydrochloride

Lobeline hydrochloride (C-07475)

α-Lobeline hydrochloride

Lobelinehydrochlonide

α-Lobeline Hydrochcloride

(-)-Lobeline hydrochloride

(–)-Lobelin (hydrochloride)

2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride

(?)-Lobeline hydrochloride

134-63-4

C22H27NO2HCl

Building Blocks

Asymmetric Synthesis

Chiral Building Blocks